PC Guard family products include special support for non-standard (custom) applications generated by the following compilers and applications:
 

- ACD FotoAngelo files (http://www.acdsystems.com)
- Active e-book compiler (http://www.ebookcompiler.com)
- Adventure Game Studio (AGS) (http://www.bigbluecup.com)
- AL Pictures Slideshow Studio! (http://www.al-soft.com)
- AutoPlay Media Studio (http://www.indigorose.com)
- Bink video player (http://www.radgametools.com)
- Brilliant Database SDK (http://www.brilliantdatabase.com)
- Dark Basic compiler (http://www.darkbasicpro.com)
- FlashJester - Jugglor (http://www.flashjester.com)
- Flash2EXE applications
- Flash2X applications (http://www.flash2X.net)
- FreeWrap applications
- Game editor applications (http://game-editor.com)
- Help and Manual compiler (http://www.helpandmanual.com)
- LabView (http://www.ni.com/labview)
- Lectora (http://www.lectora.com)
- Linder Setup Builder (http://www.lindersoftware.com)
- MatchWare Mediator (http://www.matchware.net)
- Macromedia Authorware (http://www.macromedia.com)
- Macromedia Director (http://www.macromedia.com)
- Macromedia Flash (http://www.macromedia.com)
- Microsoft Camcorder files (http://www.microsoft.com)
- Multimedia fusion applications (http://www.clickteam.com)
- NeoBook applications (http://www.neosoftware.com)
- Opus Pro applications (http://www.digitalworkshop.com)
- Photoshop droplet files (http://www.adobe.com)
- PPT to Flash Studio (http://www.pptflashstudio.com)
- Power Builder applications (http://www.sybase.com)
- Real Basic applications (http://www.realbasic.com)
- Runtime Revolution compiler (http://www.runrev.com)
- SecurePack V1/V2/V3 files  (http://www.mvps.org/skp/securepack)
- SWF Encrypt 3.0 (http://www.amayeta.com/software/swfencrypt)
- Techsmith's Camtasia files (http://www.techsmith.com)
- TrainerSoft (http://www.trainersoft.com)
- Visual DBase applications (http://www.borland.com)
- WBTExpress applications (http://www.wbtexpress.com)
- WinBatch applications (http://www.windowware.com)
- WinDev applications (http://www.windev.com)
- Zinc (http://www.multidmedia.com)